Killer cells reactive to altered-self antigens can also be alloreactive.

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Killer cells reactive to altered-self antigens can also be alloreactive.

Murine cytotoxic thymus-derived lymphocytes immunized against cells bearing foreign minor histocompatibility antigens are specific for the immunizing minor antigens and for their own major H-2 antigens; they do not lyse target cells that bear the correct minor antigens plus a different H-2 haplotype. These are referred to as "altered-self" or "self-plus-X" killer cells. Alloreactive killer cell...

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Self H-2 antigens influence the specificity of alloreactive cells

We have tested Jerne's hypothesis (9) that the phenomenon alloreactivity is explained by the existence of T cells that express germline-encoded receptors specific for major histocompatibility complex antigens and that these cells undergo no change in specificity during thymic differentiation. T cells from [F1 leads to Parent] bone marrow radiation chimeras reactive to conventional antigens are ...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1977

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.74.5.2094